open positions
graduate students
The Briney lab is accepting graduate students! We have several exciting projects available, including:
- analysis of the antibody response to candidate HIV vaccines
- discovery and characterization of broad and potently neutralizing antibodies against Lassa Fever
- systems immunology of the immune responses to hemorrhagic fever viruses, including Ebola and Lassa
- developing predictive models of human antibodies using exceptionally large immunogenetic datasets
If you’re interested in rotating or joining the lab, get in touch with us at briney@scripps.edu.
postdoctoral associate
The Briney lab is looking for a highly motivated postdoctoral associate to lead our systems biology efforts as part of the Center for Viral Systems Biology (CViSB). The mission of the CViSB is to identify molecular networks of host and viral factors that determine the outcome of infection with Ebola, Lassa, and SARS-CoV-2. This position will involve creating and analyzing single cell multi-omics datasets from acutely infected patients and convalescent survivors. Applicants should have a strong publication record and demonstrated expertise in generating and processing large-scale immune receptor datasets.
Programming experience is a plus, but is not required. If you’re an immunologist who’s interested in learning how to code, we’d be happy to teach you.
This project is a close collaboration with Kenema Government Hospital in Sierra Leone, and members of the Briney lab make regular trips to Kenema to collect samples, build infrastructure at KGH, and work with Sierra Leonean scientists. Although travel to Africa is completely optional, it’s a life changing trip!
responsibilities
- create and improve techniques for large-scale bulk and single cell sequencing of adaptive immune receptor repertoires (antibody and TCR)
- oversee and directly participate in the isolation and characterization of neutralizing monoclonal antibodies from survivors of Lassa, Ebola, and SARS-CoV-2 infection
- work closely with computational biologists to develop novel computational tools for evaluation of antibody repertoire development, maturation and function
- train and supervise junior scientists and students
qualifications
- Ph.D. in immunology, genetics, computational biology, or similar is required
- independent, highly motivated and passionate about harnessing emerging technology to answer fundamental questions about human immunology and emerging infectious diseases
- familiarity with common molecular biology techniques (cloning, protein production and purification, assessment of antibody binding/neutralization) is highly desirable
- experience performing next-generation sequencing is highly desirable, especially experience with the 10X Genomics Chromium platform or other microfluidics-based single cell analysis platforms
- experience analyzing large sequence datasets is highly desirable
- programming skills (our lab primarily uses Python) are not required but would be a plus
- our work is highly collaborative, so the ability to work productively with other Scripps and non-Scripps investigators is essential
To apply, please email your CV and a cover letter to briney@scripps.edu.
research technician
The Briney lab is looking for a highly motivated research technician to join our systems biology efforts as part of the newly funded Center for Viral Systems Biology (CViSB). The mission of the CViSB is to is to identify molecular networks of host and viral factors that determine the outcome of infection with Ebola (EBOV) and Lassa (LASV) viruses. As a leader of the CViSB’s Technology Core, this position will involve generating adaptive immune receptor repertoire (AIRR) next-generation sequencing libraries, utilization of high-throughput single-cell techniques (DropSeq, SplitSeq, 10X Genomics, etc), and functional evaluation of novel monoclonal antibodies using binding and/or neutralization assays. Previous molecular biology experience (PCR, cloning, ELISA, protein expression and purification, etc) is not strictly required but is highly desirable.
responsibilities
- Isolation and cryopreservation of peripheral blood mononuclear cells from whole blood or leukapheresis samples
- Library preparation for next-generation sequencing of adaptive immune receptor repertoires (antibody and TCR)
- Participate in the isolation and characterization of neutralizing monoclonal antibodies from survivors of Lassa and Ebola infection
- Work closely and efficiently with other scientists and students
qualifications
- Bachelor’s degree in biology, immunology, genetics, or similar is required
- Independent, highly motivated and passionate about harnessing emerging technology to answer fundamental questions about viral immunology
- Familiarity with common molecular biology techniques (cloning, protein production and purification, assessment of antibody binding/neutralization) is highly desirable
- Experience performing next-generation sequencing is highly desirable, especially experience with the 10X Genomics Chromium platform or other microfluidics-based single cell analysis platforms
- Strong interpersonal and communication skills
To apply, please email your CV and a cover letter to briney@scripps.edu.