papers – brineylab

2019

Commonality despite exceptional diversity in the baseline human antibody repertoire

Briney B, Inderbitzin A, Joyce C, Burton DR
Nature. 2018. 2019 Jan 21. doi: 10.1038/s41586-019-0879-y

2018

Massively scalable genetic analysis of antibody repertoires

Briney B, Burton DR
bioRxiv. 2018 Oct 19. doi: 10.1101/447813

2017

HIV envelope glycoform heterogeneity and localized diversity govern the initiation and maturation of a V2 apex broadly neutralizing antibody lineage

Landais E, Murrell B, Briney B, Murrell S, Rantalainen K, Berndsen ZT, Ramos A, Wickramasinghe L, Smith ML, Eren K, de Val N, Wu M, Cappelletti A, Umotoy J, Lie Y, Wrin T, Algate P, Chan-Hui PY, Karita E; IAVI Protocol C Investigators; IAVI African HIV Research Network, Ward AB, Wilson IA, Burton DR, Smith D, Pond SLK, Poignard P
Immunity. 2017 Nov 21;47(5):990-1003.e9. doi: 10.1016/j.immuni.2017.11.002

Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development

Andrabi R, Su CY, Liang CH, Shivatare SS, Briney B, Voss JE, Nawazi SK, Wu CY, Wong CH, Burton DR
Immunity. 2017 Sep 19;47(3):524-537.e3. doi: 10.1016/j.immuni.2017.08.006

Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors

Rogers TF*, Goodwin EC*, Briney B, Sok D, Beutler N, Strubel A, Nedellec R, Le K, Brown ME, Burton DR, Walker LM
Sci Immunol. 2017 Aug 18;2(14). pii: eaan6809. doi: 10.1126/sciimmunol.aan6809

Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Magnani DM*, Rogers TF*, Beutler N, Ricciardi MJ, Bailey VK, Gonzalez-Nieto L, Briney B, Sok D, Le K, Strubel A, Gutman MJ, Pedreño-Lopez N, Grubaugh ND, Silveira CGT, Maxwell HS, Domingues A, Martins MA, Lee DE, Okwuazi EE, Jean S, Strobert EA, Chahroudi A,, Silvestri G, Vanderford TH, Kallas EG, Desrosiers RC, Bonaldo MC, Whitehead SS, Burton DR, Watkins DI
Sci Transl Med. 2017 Oct 4;9(410). pii: eaan8184. doi: 10.1126/scitranslmed.aan8184

2016

Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies

Briney B*, Sok D*, Jardine JG*, Kulp DW*, Skog P*, Menis S, Jacak R, Kalyuzhniy O, de Val N, Sesterhenn F, Le KM, Ramos A, Jones M, Saye-Francisco KL, Blane TR, Spencer S, Georgeson E, Hu X, Ozorowski G, Adachi Y, Kubitz M, Sarkar A, Wilson IA, Ward AB, Nemazee D, Burton DR, Schief WR
Cell. 2016 Sep 8;166(6):1459-1470.e11. doi: 10.1016/j.cell.2016.08.005

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

Sok D*, Briney B*, Jardine JG*, Kulp DW*, Menis S*, Pauthner M, Wood A, Lee EC, Le KM, Jones M, Ramos A, Kalyuzhniy O, Adachi Y, Kubitz M, MacPherson S, Bradley A, Friedrich GA, Schief WR, Burton DR
Science. 2016 Sep 30;353(6307):1557-1560. doi: 10.1126/science.aah3945

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Jardine JG*, Kulp DW*, Havenar-Daughton C*, Sarkar A*, Briney B*, Sok D*, Sesterhenn F, Ereño-Orbea J, Kalyuzhniy O, Deresa I, Hu X, Spencer S, Jones M, Georgeson E, Adachi Y, Kubitz M, deCamp AC, Julien JP, Wilson IA, Burton DR, Crotty S, Schief WR
Science. 2016 Mar 25;351(6280):1458-63. doi: 10.1126/science.aad9195

Clonify: unseeded antibody lineage assignment from next-generation sequencing data

Briney B, Le K,, Zhu J, Burton DR
Sci Rep. 2016 Apr 22;6:23901. doi: 10.1038/srep23901

Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design

Jardine JG*, Sok D*, Julien JP*, Briney B*, Sarkar A*, Liang CH, Scherer EA, Henry Dunand CJ, Adachi Y, Diwanji D, Hsueh J, Jones M, Kalyuzhniy O, Kubitz M, Spencer S, Pauthner M, Saye-Francisco KL, Sesterhenn F, Wilson PC, Galloway DM, Stanfield RL, Wilson IA, Burton DR, Schief WR
PLoS Pathog. 2016 Aug 25;12(8):e1005815. doi: 10.1371/journal.ppat.1005815

A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 ninding and its camouflaging glycans

Sok D, Pauthner M, Briney B, Lee JH, Saye-Francisco KL, Hsueh J, Ramos A, Le KM, Jones M, Jardine JG, Bastidas R, Sarkar A, Liang CH, Shivatare SS, Wu CY, Schief WR, Wong CH, Wilson IA, Ward AB, Zhu J, Poignard P, Burton DR
Immunity. 2016 Jul 19;45(1):31-45. doi: 10.1016/j.immuni.2016.06.026

Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer

Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, Mohammed AUR, Huang J, Gumber S, Garcia A, Kasturi SP, Pulendran B, Moore JP0, Ahmed R, Seumois G, Burton DR, Sanders RW, Silvestri G, Crotty S
Cell Rep. 2016 Nov 22;17(9):2195-2209. doi: 10.1016/j.celrep.2016.10.085